| 1. Round | 24/02/2022 | Academia Puerto Cabello | - | Portuguesa FC | 1:1 | ||||
| 2. Round | 06/03/2022 | Deportivo La Guaira | - | Academia Puerto Cabello | 2:1 |  |
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| 3. Round | 10/03/2022 | Academia Puerto Cabello | - | Aragua FC | 2:1 | ||||
| 4. Round | 18/03/2022 | Deportivo Táchira | - | Academia Puerto Cabello | 1:1 | ||||
| 5. Round | 25/03/2022 | Hermanos Colmenarez | - | Academia Puerto Cabello | 4:1 | ||||
| 6. Round | 01/04/2022 | Academia Puerto Cabello | - | Caracas FC | 0:0 | |
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| 7. Round | 10/04/2022 | Mineros de Guayana | - | Academia Puerto Cabello | 2:0 | |
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| 8. Round | 15/04/2022 | Academia Puerto Cabello | - | Monagas | 0:2 | ||||
| 10. Round | 30/04/2022 | Academia Puerto Cabello | - | Estudiantes de Mérida | 1:0 | ||||
| 11. Round | 08/05/2022 | Universidad Central | - | Academia Puerto Cabello | 2:2 | ||||
| 12. Round | 15/05/2022 | Academia Puerto Cabello | - | Carabobo FC | 1:1 | ||||
| 13. Round | 20/05/2022 | Zamora FC | - | Academia Puerto Cabello | 1:0 | ||||
| 14. Round | 29/05/2022 | Academia Puerto Cabello | - | Metropolitanos FC | 0:2 | ||||
| 15. Round | 04/06/2022 | Zulia FC | - | Academia Puerto Cabello | 4:1 |
Panama