| 2. Round | 21/08/2021 | FC Speyer 09 | - | Wormatia Worms | 0:4 | ||||
| 3. Round | 25/08/2021 | FC Speyer 09 | - | TSG Pfeddersheim | 1:0 | ||||
| 6. Round | 12/09/2021 | SV 07 Elversberg II | - | FC Speyer 09 | 2:3 | ||||
| 7. Round | 18/09/2021 | FC Speyer 09 | - | FSV Jägersburg | 0:5 | ||||
| 9. Round | 26/09/2021 | FC Speyer 09 | - | FV 07 Diefflen | 3:4 | ||||
| 4. Round | 05/10/2021 | Arminia Ludwigshafen | - | FC Speyer 09 | 3:2 | ||||
| 11. Round | 10/10/2021 | FC Speyer 09 | - | FC Hertha Wiesbach | 1:2 | ||||
| 12. Round | 18/10/2021 | FC Speyer 09 | - | TuS Mechtersheim | 2:3 | ||||
| 14. Round | 27/10/2021 | TSG Pfeddersheim | - | FC Speyer 09 | 3:3 | ||||
| 16. Round | 08/11/2021 | FV Dudenhofen | - | FC Speyer 09 | 5:2 | ||||
| 18. Round | 20/11/2021 | FSV Jägersburg | - | FC Speyer 09 | 4:2 | ||||
| 19. Round | 24/11/2021 | FC Speyer 09 | - | SV Röchling Völklingen | 0:1 | ||||
| 20. Round | 27/11/2021 | FV 07 Diefflen | - | FC Speyer 09 | 2:1 | ||||
| 21. Round | 26/02/2022 | FC Speyer 09 | - | FV Eppelborn | 1:2 | ||||
| 22. Round | 05/03/2022 | FC Hertha Wiesbach | - | FC Speyer 09 | 8:1 |
Germany