| 1. Round | 16/01/2022 | Alianza | - | Isidro Metapán | 0:2 | ||||
| 2. Round | 22/01/2022 | Jocoro FC | - | Alianza | 3:2 | ||||
| 3. Round | 27/01/2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 5. Round | 06/02/2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Round | 10/02/2022 | Santa Tecla FC | - | Alianza | 2:3 | ||||
| 7. Round | 13/02/2022 | Alianza | - | Platense Zacatecoluca | 1:0 | ||||
| 8. Round | 20/02/2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Round | 23/02/2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 4. Round | 03/03/2022 | Alianza | - | FAS | 1:1 | ||||
| 11. Round | 06/03/2022 | Alianza | - | CD Águila | 0:0 | ||||
| 12. Round | 13/03/2022 | Isidro Metapán | - | Alianza | 0:0 |  |
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| 13. Round | 20/03/2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 14. Round | 25/03/2022 | AD Chalatenango | - | Alianza | 2:0 | |
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| 15. Round | 03/04/2022 | FAS | - | Alianza | 1:3 | ||||
| 16. Round | 10/04/2022 | Luis Ángel Firpo | - | Alianza | 0:1 | ||||
| 17. Round | 13/04/2022 | Alianza | - | Santa Tecla FC | 2:2 |  |
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| 18. Round | 17/04/2022 | Platense Zacatecoluca | - | Alianza | 0:1 | ||||
| 19. Round | 24/04/2022 | Alianza | - | Municipal Limeño | 4:0 | |
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| 20. Round | 29/04/2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 21. Round | 01/05/2022 | Atlético Marte | - | Alianza | 0:3 | |
El Salvador