| 1. Round | 11/01/2025 | Atlético San Luis | - | UANL Tigres | 1:3 | ||||
| 3. Round | 25/01/2025 | Atlético San Luis | - | Club Necaxa | 0:3 | ||||
| 4. Round | 29/01/2025 | CF América | - | Atlético San Luis | 3:0 | ||||
| 5. Round | 03/02/2025 | Atlético San Luis | - | Pumas UNAM | 2:3 | ||||
| 6. Round | 08/02/2025 | Gallos Blancos | - | Atlético San Luis | 1:0 |  |
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| 7. Round | 17/02/2025 | Atlético San Luis | - | Club León | 1:2 | ||||
| 8. Round | 23/02/2025 | CF Monterrey | - | Atlético San Luis | 3:1 | |
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| 9. Round | 27/02/2025 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | |
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| 10. Round | 03/03/2025 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 11. Round | 08/03/2025 | Atlético San Luis | - | FC Juárez | 1:0 | ||||
| 12. Round | 16/03/2025 | Cruz Azul | - | Atlético San Luis | 3:0 | ||||
| 13. Round | 31/03/2025 | Santos Laguna | - | Atlético San Luis | 2:3 | ||||
| 14. Round | 06/04/2025 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 15. Round | 11/04/2025 | Club Tijuana | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 17/04/2025 | Atlético San Luis | - | Deportivo Toluca | 0:1 | ||||
| 17. Round | 21/04/2025 | Atlético San Luis | - | CF Pachuca | 2:1 |
Mexico