2. Round 05/09/2021 AS Nancy Lorraine [Youth B] - FC Annecy [Youth B] 4:2
3. Round 12/09/2021 FC Annecy [Youth B] - RC Strasbourg [Youth B] 1:2
5. Round 26/09/2021 FC Annecy [Youth B] - FC Bourg-Péronnas [Youth B] 1:0
6. Round 03/10/2021 Racing Besançon [Youth B] - FC Annecy [Youth B] 2:1
7. Round 10/10/2021 FC Annecy [Youth B] - AJ Auxerre [Youth B] 1:3
8. Round 17/10/2021 FC Metz [Youth B] - FC Annecy [Youth B] 1:0
9. Round 24/10/2021 FC Annecy [Youth B] - Olympique Lyonnais [Youth B] 2:1
10. Round 14/11/2021 FC Sochaux [Youth B] - FC Annecy [Youth B] 3:3
11. Round 21/11/2021 FC Annecy [Youth B] - FC Lyon [Youth B] 1:2
12. Round 28/11/2021 FC Annecy [Youth B] - Dijon FCO [Youth B] 3:1
13. Round 05/12/2021 FC Mulhouse [Youth B] - FC Annecy [Youth B] 1:3
14. Round 16/01/2022 FC Annecy [Youth B] - AS Nancy Lorraine [Youth B] 3:1
15. Round 23/01/2022 RC Strasbourg [Youth B] - FC Annecy [Youth B] 4:0
16. Round 27/02/2022 FC Annecy [Youth B] - ASPTT Dijon [Youth B] 3:1
18. Round 06/03/2022 FC Annecy [Youth B] - Racing Besançon [Youth B] 1:1
19. Round 13/03/2022 AJ Auxerre [Youth B] - FC Annecy [Youth B] 2:0
20. Round 20/03/2022 FC Annecy [Youth B] - FC Metz [Youth B] 2:1
21. Round 27/03/2022 Olympique Lyonnais [Youth B] - FC Annecy [Youth B] 2:0
23. Round 10/04/2022 FC Lyon [Youth B] - FC Annecy [Youth B] 1:1
24. Round 17/04/2022 Dijon FCO [Youth B] - FC Annecy [Youth B] 2:1
22. Round 26/04/2022 FC Annecy [Youth B] - FC Sochaux [Youth B] 1:5
25. Round 01/05/2022 FC Annecy [Youth B] - FC Mulhouse [Youth B] 1:2
26. Round 15/05/2022 SAS Épinal [Youth B] - FC Annecy [Youth B] 2:2