| 1. Round | 15/07/2021 | FC Botoşani | - | FCSB | 0:0 | ||||
| 2. Round | 25/07/2021 | FCSB | - | CS Universitatea Craiova | 4:1 | ||||
| 3. Round | 01/08/2021 | UTA Arad | - | FCSB | 1:1 | ||||
| 4. Round | 08/08/2021 | FCSB | - | Gaz Metan Mediaş | 2:1 | ||||
| 7. Round | 29/08/2021 | CFR Cluj | - | FCSB | 4:1 | ||||
| 8. Round | 12/09/2021 | FCSB | - | Dinamo Bucureşti | 6:0 | ||||
| 11. Round | 01/10/2021 | Chindia Târgoviște | - | FCSB | 0:1 | ||||
| 12. Round | 16/10/2021 | FCSB | - | CS Mioveni | 3:0 | ||||
| 14. Round | 31/10/2021 | FCSB | - | Argeș Pitești | 2:1 | ||||
| 15. Round | 07/11/2021 | FC Voluntari | - | FCSB | 0:0 | ||||
| 22. Round | 23/01/2022 | FCSB | - | CFR Cluj | 3:3 |  |
Romania