| 5. Round | 04/09/2010 | Milton Keynes Dons | - | Hartlepool United | 1:0 | ||||
| 6. Round | 11/09/2010 | Hartlepool United | - | Exeter City | 2:3 | ||||
| 7. Round | 18/09/2010 | Brentford FC | - | Hartlepool United | 0:0 | ||||
| 8. Round | 25/09/2010 | Hartlepool United | - | Walsall FC | 2:1 | ||||
| 9. Round | 28/09/2010 | Hartlepool United | - | Carlisle United | 0:4 | ||||
| 10. Round | 02/10/2010 | Plymouth Argyle | - | Hartlepool United | 0:1 | ||||
| 11. Round | 09/10/2010 | Hartlepool United | - | Peterborough United | 2:0 | ||||
| 14. Round | 30/10/2010 | Dagenham & Redbridge | - | Hartlepool United | 1:1 | ||||
| 26. Round | 18/01/2011 | Bristol Rovers | - | Hartlepool United | 0:0 | ||||
| 39. Round | 25/03/2011 | Hartlepool United | - | Rochdale AFC | 0:2 | ||||
| 42. Round | 16/04/2011 | Sheffield Wednesday | - | Hartlepool United | 2:0 | ||||
| 43. Round | 22/04/2011 | Hartlepool United | - | Tranmere Rovers | 1:1 | ||||
| 45. Round | 30/04/2011 | Hartlepool United | - | AFC Bournemouth | 2:2 |
Ireland