| 22. Round | 21/02/2016 | Arminia Bielefeld | - | SC Paderborn 07 | 1:1 | ||||
| 23. Round | 26/02/2016 | SC Paderborn 07 | - | RB Leipzig | 0:1 | ||||
| 24. Round | 01/03/2016 | Karlsruher SC | - | SC Paderborn 07 | 0:0 | ||||
| 25. Round | 05/03/2016 | SC Paderborn 07 | - | SpVgg Greuther Fürth | 1:1 | ||||
| 26. Round | 11/03/2016 | FC St. Pauli | - | SC Paderborn 07 | 3:4 | ||||
| 27. Round | 18/03/2016 | SC Paderborn 07 | - | MSV Duisburg | 0:0 | ||||
| 28. Round | 01/04/2016 | Eintracht Braunschweig | - | SC Paderborn 07 | 2:1 | ||||
| 29. Round | 08/04/2016 | SC Paderborn 07 | - | 1. FC Union Berlin | 0:4 | ||||
| 30. Round | 15/04/2016 | FSV Frankfurt | - | SC Paderborn 07 | 0:2 | ||||
| 31. Round | 23/04/2016 | 1. FC Heidenheim 1846 | - | SC Paderborn 07 | 1:1 | ||||
| 32. Round | 29/04/2016 | SC Paderborn 07 | - | SC Freiburg | 1:2 | ||||
| 33. Round | 08/05/2016 | TSV 1860 München | - | SC Paderborn 07 | 1:0 | ||||
| 34. Round | 15/05/2016 | SC Paderborn 07 | - | 1. FC Nürnberg | 0:1 |
Germany