| 14. Round | 27/11/2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
| 20. Round | 23/01/2022 | Heracles Almelo | - | Go Ahead Eagles | 1:1 | ||||
| 22. Round | 13/02/2022 | Go Ahead Eagles | - | AZ Alkmaar | 1:4 | ||||
| 23. Round | 20/02/2022 | FC Twente | - | Go Ahead Eagles | 2:2 | ||||
| 24. Round | 27/02/2022 | Go Ahead Eagles | - | AFC Ajax | 2:1 |  |
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| 25. Round | 05/03/2022 | Go Ahead Eagles | - | FC Utrecht | 1:1 | ||||
| 26. Round | 12/03/2022 | Sparta Rotterdam | - | Go Ahead Eagles | 1:0 | ||||
| 27. Round | 19/03/2022 | Go Ahead Eagles | - | SC Cambuur | 3:0 | ||||
| 28. Round | 03/04/2022 | PEC Zwolle | - | Go Ahead Eagles | 0:1 | ||||
| 29. Round | 08/04/2022 | Go Ahead Eagles | - | Willem II | 4:0 | ||||
| 30. Round | 24/04/2022 | Fortuna Sittard | - | Go Ahead Eagles | 1:0 |
Netherlands
