| 1. Round | 25/01/2025 | 2 de Mayo | - | Club Nacional | 0:0 | ||||
| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | ||||
| 6. Round | 22/02/2025 | Sportivo Ameliano | - | Club Nacional | 2:1 | ||||
| 7. Round | 01/03/2025 | Club Nacional | - | Atlético Tembetary | 1:0 | ||||
| 8. Round | 10/03/2025 | Sportivo Luqueño | - | Club Nacional | 2:1 |  |
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| 9. Round | 17/03/2025 | Club Nacional | - | Sportivo Trinidense | 1:1 | ||||
| 10. Round | 22/03/2025 | Club Olimpia | - | Club Nacional | 0:1 | ||||
| 11. Round | 30/03/2025 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 12. Round | 07/04/2025 | Club Nacional | - | 2 de Mayo | 1:0 | ||||
| 13. Round | 11/04/2025 | Libertad | - | Club Nacional | 1:0 | ||||
| 14. Round | 16/04/2025 | Club Nacional | - | Cerro Porteño | 1:3 |
Paraguay