| 13. Round | 23/10/2010 | Plymouth Argyle | - | Huddersfield Town | 2:1 | ||||
| 14. Round | 30/10/2010 | Oldham Athletic | - | Plymouth Argyle | 4:2 | ||||
| 15. Round | 02/11/2010 | Plymouth Argyle | - | Bristol Rovers | 3:1 | ||||
| 16. Round | 13/11/2010 | Tranmere Rovers | - | Plymouth Argyle | 1:0 | ||||
| 17. Round | 20/11/2010 | Plymouth Argyle | - | Brentford FC | 1:2 | ||||
| 18. Round | 23/11/2010 | Plymouth Argyle | - | Dagenham & Redbridge | 2:1 | ||||
| 20. Round | 11/12/2010 | Plymouth Argyle | - | Exeter City | 2:0 |  |
Ireland