| 4. Round | 15/08/2010 | Club San Luis | - | Monarcas Morelia | 1:0 | ||||
| 5. Round | 21/08/2010 | Estudiantes Tecos | - | Club San Luis | 3:2 | ||||
| 6. Round | 29/08/2010 | Club San Luis | - | Atlante | 2:1 | ||||
| 7. Round | 12/09/2010 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 8. Round | 19/09/2010 | Club San Luis | - | CF Pachuca | 1:0 | ||||
| 9. Round | 25/09/2010 | Jaguares Chiapas | - | Club San Luis | 2:1 | ||||
| 10. Round | 03/10/2010 | Club San Luis | - | UANL Tigres | 1:0 | ||||
| 11. Round | 10/10/2010 | Atlas Guadalajara | - | Club San Luis | 2:1 | ||||
| 12. Round | 16/10/2010 | Club San Luis | - | Gallos Blancos (old) | 3:2 | ||||
| 13. Round | 23/10/2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
| 14. Round | 29/10/2010 | Club San Luis | - | CF América | 1:2 | ||||
| 15. Round | 31/10/2010 | Deportivo Toluca | - | Club San Luis | 1:2 |  |
|||
| 16. Round | 06/11/2010 | Club San Luis | - | Santos Laguna | 1:1 | ||||
| 17. Round | 13/11/2010 | Cruz Azul | - | Club San Luis | 1:0 |
Mexico