| 2. Round | 21/08/2021 | Eintracht Frankfurt | - | FC Augsburg | 0:0 |  |
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| 3. Round | 28/08/2021 | FC Augsburg | - | Bayer Leverkusen | 1:4 | ||||
| 6. Round | 26/09/2021 | SC Freiburg | - | FC Augsburg | 3:0 | ||||
| 7. Round | 02/10/2021 | Borussia Dortmund | - | FC Augsburg | 2:1 | |
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| 9. Round | 22/10/2021 | 1. FSV Mainz 05 | - | FC Augsburg | 4:1 | ||||
| 10. Round | 31/10/2021 | FC Augsburg | - | VfB Stuttgart | 4:1 | |
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| 12. Round | 19/11/2021 | FC Augsburg | - | Bayern München | 2:1 | ||||
| 23. Round | 19/02/2022 | FC Augsburg | - | SC Freiburg | 1:2 | ||||
| 24. Round | 27/02/2022 | FC Augsburg | - | Borussia Dortmund | 1:1 | ||||
| 25. Round | 04/03/2022 | Arminia Bielefeld | - | FC Augsburg | 0:1 | |
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| 27. Round | 19/03/2022 | VfB Stuttgart | - | FC Augsburg | 3:2 | ||||
| 28. Round | 03/04/2022 | FC Augsburg | - | VfL Wolfsburg | 3:0 | ||||
| 26. Round | 06/04/2022 | FC Augsburg | - | 1. FSV Mainz 05 | 2:1 | |
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| 31. Round | 24/04/2022 | VfL Bochum | - | FC Augsburg | 0:2 | ||||
| 32. Round | 30/04/2022 | FC Augsburg | - | 1. FC Köln | 1:4 | |
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| 33. Round | 08/05/2022 | RB Leipzig | - | FC Augsburg | 4:0 | ||||
| 34. Round | 14/05/2022 | FC Augsburg | - | SpVgg Greuther Fürth | 2:1 | |
Ecuador