| 12. Round | 20/11/2021 | West Ham United U23 | - | Manchester City U23 | 1:0 |  |
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| 14. Round | 04/12/2021 | Tottenham Hotspur U23 | - | Manchester City U23 | 3:0 | ||||
| 16. Round | 09/01/2022 | Blackburn Rovers U23 | - | Manchester City U23 | 3:5 | ||||
| 18. Round | 24/01/2022 | Chelsea FC U23 | - | Manchester City U23 | 0:1 | ||||
| 19. Round | 07/02/2022 | Derby County U23 | - | Manchester City U23 | 0:5 | ||||
| 20. Round | 20/02/2022 | Manchester City U23 | - | West Ham United U23 | 2:0 |  |
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| 21. Round | 28/02/2022 | Leicester City U23 | - | Manchester City U23 | 0:0 | ||||
| 22. Round | 12/03/2022 | Crystal Palace U23 | - | Manchester City U23 | 1:2 | ||||
| 23. Round | 20/03/2022 | Manchester City U23 | - | Liverpool FC U23 | 0:0 | ||||
| 24. Round | 04/04/2022 | Arsenal FC U23 | - | Manchester City U23 | 3:3 | ||||
| 25. Round | 22/04/2022 | Leeds United U23 | - | Manchester City U23 | 1:3 |
Portugal
Guinea-Bissau