| 1. Round | 11/09/2021 | Rot-Weiß Oberhausen [Youth] | - | Borussia Dortmund [Youth] | 0:3 | ||||
| 2. Round | 19/09/2021 | Borussia Dortmund [Youth] | - | SC Paderborn 07 [Youth] | 3:1 |  |
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| 3. Round | 25/09/2021 | Fortuna Köln [Youth] | - | Borussia Dortmund [Youth] | 1:4 | |
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| 4. Round | 03/10/2021 | Borussia Dortmund [Youth] | - | MSV Duisburg [Youth] | 1:1 |  |
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| 5. Round | 16/10/2021 | Arminia Bielefeld [Youth] | - | Borussia Dortmund [Youth] | 1:2 | |
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| 6. Round | 24/10/2021 | Borussia Dortmund [Youth] | - | FC Schalke 04 [Youth] | 4:0 | |
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| 7. Round | 30/10/2021 | 1. FC Köln [Youth] | - | Borussia Dortmund [Youth] | 0:1 | |
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| 8. Round | 28/11/2021 | Borussia Dortmund [Youth] | - | Fortuna Düsseldorf [Youth] | 9:1 | |
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| 10. Round | 04/02/2022 | Borussia Dortmund [Youth] | - | Bayer Leverkusen [Youth] | 3:1 | |
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| 11. Round | 13/02/2022 | Wuppertaler SV [Youth] | - | Borussia Dortmund [Youth] | 0:4 | |
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| 14. Round | 03/04/2022 | Bor. Mönchengladbach [Youth] | - | Borussia Dortmund [Youth] | 0:6 | |
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| 15. Round | 09/04/2022 | Borussia Dortmund [Youth] | - | VfL Bochum [Youth] | 3:0 | |
Switzerland
England