| 1. Round | 07/08/2010 | OGC Nice | - | Valenciennes FC | 0:0 |  |
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| 2. Round | 14/08/2010 | Valenciennes FC | - | Olympique Marseille | 3:2 | ||||
| 3. Round | 21/08/2010 | AJ Auxerre | - | Valenciennes FC | 1:1 | ||||
| 4. Round | 28/08/2010 | Valenciennes FC | - | Montpellier HSC | 0:1 | |
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| 5. Round | 11/09/2010 | Olympique Lyonnais | - | Valenciennes FC | 1:1 | ||||
| 6. Round | 18/09/2010 | Valenciennes FC | - | RC Lens | 1:1 | ||||
| 7. Round | 26/09/2010 | Stade Brestois 29 | - | Valenciennes FC | 1:0 | ||||
| 8. Round | 02/10/2010 | Valenciennes FC | - | SM Caen | 2:1 | ||||
| 12. Round | 06/11/2010 | Girondins Bordeaux | - | Valenciennes FC | 1:1 | |
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| 14. Round | 20/11/2010 | AS Nancy Lorraine | - | Valenciennes FC | 2:0 | |
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| 15. Round | 27/11/2010 | Valenciennes FC | - | AC Arles-Avignon | 3:0 | ||||
| 13. Round | 01/12/2010 | Valenciennes FC | - | AS Saint-Étienne | 1:1 | |
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| 16. Round | 04/12/2010 | FC Sochaux | - | Valenciennes FC | 2:1 | ||||
| 17. Round | 11/12/2010 | Valenciennes FC | - | Paris Saint-Germain | 1:2 | ||||
| 19. Round | 22/12/2010 | Valenciennes FC | - | Toulouse FC | 2:1 |
France