| 1. Round | 24/07/2021 | Jagiellonia Białystok | - | Lechia Gdańsk | 1:1 | ||||
| 2. Round | 01/08/2021 | Raków Częstochowa | - | Jagiellonia Białystok | 0:3 | ||||
| 3. Round | 07/08/2021 | Jagiellonia Białystok | - | Bruk-Bet Termalica Nieciecza | 1:0 | ||||
| 4. Round | 16/08/2021 | Jagiellonia Białystok | - | Górnik Zabrze | 1:3 | ||||
| 5. Round | 21/08/2021 | KS Cracovia | - | Jagiellonia Białystok | 2:1 |  |
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| 6. Round | 27/08/2021 | Warta Poznań | - | Jagiellonia Białystok | 1:1 | |
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| 7. Round | 11/09/2021 | Jagiellonia Białystok | - | FKS Stal Mielec | 1:1 | |
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| 8. Round | 18/09/2021 | Wisła Płock | - | Jagiellonia Białystok | 3:0 | ||||
| 12. Round | 23/10/2021 | Pogoń Szczecin | - | Jagiellonia Białystok | 4:1 | ||||
| 13. Round | 30/10/2021 | Jagiellonia Białystok | - | Piast Gliwice | 3:3 |  |
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| 15. Round | 20/11/2021 | Jagiellonia Białystok | - | Wisła Kraków | 3:1 |  |
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| 16. Round | 28/11/2021 | Legia Warszawa | - | Jagiellonia Białystok | 1:0 | ||||
| 17. Round | 04/12/2021 | Jagiellonia Białystok | - | Górnik Łęczna | 1:2 | |
Poland