| 1. Round | 29/08/2021 | CD Badajoz | - | CF Talavera | 2:0 | ||||
| 2. Round | 04/09/2021 | RC Celta B | - | CD Badajoz | 0:0 | ||||
| 3. Round | 10/09/2021 | CD Badajoz | - | Inter de Madrid | 1:0 | ||||
| 4. Round | 18/09/2021 | Deportivo La Coruña | - | CD Badajoz | 1:0 | ||||
| 5. Round | 25/09/2021 | Real Unión | - | CD Badajoz | 1:2 | ||||
| 6. Round | 02/10/2021 | CD Badajoz | - | Cultural Leonesa | 3:3 | ||||
| 7. Round | 10/10/2021 | Racing Ferrol | - | CD Badajoz | 0:1 | ||||
| 8. Round | 17/10/2021 | CD Badajoz | - | Racing Santander | 0:1 | ||||
| 9. Round | 24/10/2021 | UD SS Reyes | - | CD Badajoz | 0:0 |  |
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| 10. Round | 30/10/2021 | CD Badajoz | - | Extremadura UD | 2:0 | ||||
| 11. Round | 05/11/2021 | Zamora CF | - | CD Badajoz | 1:1 | ||||
| 12. Round | 14/11/2021 | CD Badajoz | - | UD Logroñés | 1:2 | ||||
| 13. Round | 20/11/2021 | Unionistas CF | - | CD Badajoz | 2:2 | ||||
| 14. Round | 27/11/2021 | CD Badajoz | - | SD Logroñés | 2:2 | ||||
| 15. Round | 05/12/2021 | Athletic Bilbao B | - | CD Badajoz | 0:0 | |
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| 16. Round | 10/12/2021 | CD Badajoz | - | CD Tudelano | 2:1 | |
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| 18. Round | 08/01/2022 | CD Badajoz | - | Real Valladolid B | 1:2 | |
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| 19. Round | 23/01/2022 | CD Calahorra | - | CD Badajoz | 1:0 |
Spain