| 3. Round | 30/01/2005 | Dorados de Sinaloa | - | Puebla FC | 0:0 | ||||
| 4. Round | 06/02/2005 | Puebla FC | - | CF América | 2:2 | ||||
| 5. Round | 13/02/2005 | Santos Laguna | - | Puebla FC | 2:0 |  |
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| 6. Round | 20/02/2005 | Puebla FC | - | UAG Tecos | 0:3 | ||||
| 7. Round | 27/02/2005 | Puebla FC | - | Jaguares Chiapas | 1:0 | ||||
| 8. Round | 05/03/2005 | CF Monterrey | - | Puebla FC | 4:1 | ||||
| 10. Round | 20/03/2005 | Monarcas Morelia | - | Puebla FC | 3:1 |  |
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| 11. Round | 02/04/2005 | Puebla FC | - | Deportivo Guadalajara | 4:1 | |
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| 12. Round | 10/04/2005 | Pumas UNAM | - | Puebla FC | 1:0 | ||||
| 13. Round | 16/04/2005 | Puebla FC | - | Atlante | 2:1 | ||||
| 14. Round | 21/04/2005 | CF Pachuca | - | Puebla FC | 1:1 | ||||
| 15. Round | 24/04/2005 | Puebla FC | - | Deportivo Toluca | 0:0 | ||||
| 16. Round | 30/04/2005 | Veracruz (old) | - | Puebla FC | 2:1 |
Mexico