| 1. Round | 05/02/2025 | Real Hope | - | Cruz Azul | 0:2 |  |
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| 1. Round | 12/02/2025 | Cruz Azul | - | Real Hope | 5:0 | |
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| Round of 16 | 12/03/2025 | Cruz Azul | - | Seattle Sounders | 4:1 | |
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| Quarter-finals | 02/04/2025 | CF América | - | Cruz Azul | 0:0 | ||||
| Quarter-finals | 09/04/2025 | Cruz Azul | - | CF América | 2:1 | |
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| Semi-finals | 24/04/2025 | UANL Tigres | - | Cruz Azul | 1:1 | |
Mexico