| 24. Round | 01/03/2022 | FC Thun | - | Neuchâtel Xamax FCS | 1:2 | ||||
| 25. Round | 04/03/2022 | Neuchâtel Xamax FCS | - | FC Vaduz | 2:4 | ||||
| 26. Round | 12/03/2022 | FC Wil 1900 | - | Neuchâtel Xamax FCS | 2:0 | ||||
| 28. Round | 01/04/2022 | FC Schaffhausen | - | Neuchâtel Xamax FCS | 2:1 | ||||
| 31. Round | 22/04/2022 | FC Vaduz | - | Neuchâtel Xamax FCS | 2:0 |  |
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| 33. Round | 06/05/2022 | Stade-Lausanne-Ouchy | - | Neuchâtel Xamax FCS | 1:3 | |
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| 34. Round | 10/05/2022 | Neuchâtel Xamax FCS | - | Yverdon Sport FC | 1:1 | ||||
| 35. Round | 14/05/2022 | FC Winterthur | - | Neuchâtel Xamax FCS | 3:1 | |
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| 36. Round | 21/05/2022 | Neuchâtel Xamax FCS | - | FC Wil 1900 | 5:2 |
Ivory Coast