| 4. Round | 29/07/2021 | San Antonio FC | - | El Paso Locomotive | 1:2 | ||||
| 4. Round | 01/08/2021 | El Paso Locomotive | - | Real Monarchs SLC | 3:1 | ||||
| 5. Round | 05/08/2021 | El Paso Locomotive | - | San Antonio FC | 2:0 | ||||
| 5. Round | 08/08/2021 | El Paso Locomotive | - | Austin Bold | 3:0 |  |
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| 5. Round | 15/08/2021 | New Mexico United | - | El Paso Locomotive | 1:1 | ||||
| 5. Round | 22/08/2021 | El Paso Locomotive | - | Rio Grande Valley FC | 3:1 | ||||
| 5. Round | 29/08/2021 | San Antonio FC | - | El Paso Locomotive | 2:1 |  |
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| 6. Round | 16/09/2021 | Colorado Springs Switchbacks | - | El Paso Locomotive | 0:0 | |
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| 6. Round | 23/09/2021 | Austin Bold | - | El Paso Locomotive | 2:2 | ||||
| 6. Round | 30/09/2021 | El Paso Locomotive | - | Real Monarchs SLC | 1:0 | ||||
| 7. Round | 18/10/2021 | Los Angeles Galaxy II | - | El Paso Locomotive | 5:0 | |
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| 7. Round | 21/10/2021 | El Paso Locomotive | - | Austin Bold | 3:0 | ||||
| 7. Round | 25/10/2021 | El Paso Locomotive | - | OKC Energy FC | 4:0 | ||||
| 7. Round | 31/10/2021 | Rio Grande Valley FC | - | El Paso Locomotive | 4:1 |
England