| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 | |
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| 3. Round | 14/08/2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | ||||
| 6. Round | 21/08/2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Round | 28/08/2022 | Plaza Colonia | - | Defensor Sporting | 0:1 |  |
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| 4. Round | 03/09/2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | ||||
| 7. Round | 11/09/2022 | River Plate | - | Defensor Sporting | 0:1 | |
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| 8. Round | 16/09/2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Round | 20/09/2022 | Fénix | - | Defensor Sporting | 0:0 | ||||
| 10. Round | 26/09/2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| 11. Round | 02/10/2022 | Defensor Sporting | - | Albion | 2:0 | ||||
| 12. Round | 08/10/2022 | Nacional | - | Defensor Sporting | 1:1 | |
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| 13. Round | 13/10/2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Round | 15/10/2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 | ||||
| 15. Round | 22/10/2022 | Defensor Sporting | - | Rentistas | 2:3 | |
Uruguay