| 18. Round | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03/12/2021 | 22:30 | Libertad |
|
- |
|
River Plate | 5:0 (2:0) | |
| 04/12/2021 | 21:15 | 12 de Octubre de Itauguá |
|
- |
|
Sol de América | 1:0 (0:0) | |
| 04/12/2021 | 21:15 | Sportivo Luqueño |
|
- |
|
Guaireña FC | 0:1 (0:0) | |
| 04/12/2021 | 23:30 | Guaraní |
|
- |
|
Cerro Porteño | 2:2 (1:0) | |
| 05/12/2021 | 22:30 | Club Nacional |
|
- |
|
Club Olimpia | 1:3 (1:1) | |
