Preliminary
04/08/2021 14:00 Feniks Pidmonastyr - Munkács 2:0
15:00 Skoruk Tomakivka - FC Trostianets 1:0
15:00 Olimpiya Savyntsi - Lyubomyr Stavyshche 6:0
16:00 Karpaty Lviv - AFSC Kiev 3:0
16:00 Livyi Bereh - SK Poltava 1:0 aet
1. Round
17/08/2021 15:00 Skoruk Tomakivka - FC Viktoriya Mykolaivka 4:2
18/08/2021 14:00 Feniks Pidmonastyr - Prykarpattya Ivano-Frankivsk 2:6
14:00 PFC Sumy - Metalurg Zaporizhya 0:1
14:00 Tavriya Simferopol - FK Dnipro Cherkasy 3:2
15:00 Epitsentr Dunaivtsi - FK Podillya-Khmelnitskiy 3:0
15:00 FC Uzhhorod - Niva Ternopil 0:1
15:00 Chayka Kyiv - FC Chernigov 3:5 pso
15:00 FSK Mariupol - Metalist 1925 Kharkiv 1:3
15:00 Olimpiya Savyntsi - FK Vovchansk 0:1
15:00 Peremoha Dnipro - Hirnyk-Sport 1:2
15:00 Real Pharma Odessa - FK VPK-Ahro Shevchenkivka 0:2
15:00 Balkany Zorya - Enerhiya Nova Kakhovka 4:2
15:00 MFK Mikolaiv - Kryvbas Kryvyi Rih 3:1 pso
15:00 FC Nikopol-NPHU - Kristal Kherson 2:0
15:30 FK Bukovina - Ahrobiznes Volochysk 2:0 aet
15:30 FC Dinaz Vyshhorod - FK Obolon 1:3
15:30 FK Nyva Vinnytsia - Volyn Lutsk 3:5 pso
16:00 Karpaty Lviv - Karpaty Halych 1:0
16:00 Rubikon Kiev - Polissya Zhytomyr 0:5
16:00 Livyi Bereh - Olimpik Donetsk 2:3
16:00 Alians Lypova Dolyna - Avangard Kramatorsk 2:1
17:00 FC LNZ Cherkasy - FK Kremin 1:0
2. Round
31/08/2021 13:00 Epitsentr Dunaivtsi - Niva Ternopil 1:0
14:30 FK Bukovina - Prykarpattya Ivano-Frankivsk 2:4 pso
14:30 FC Nikopol-NPHU - Tavriya Simferopol 0:3
14:30 Balkany Zorya - FK VPK-Ahro Shevchenkivka 1:3 aet
15:00 FC Chernigov - Alians Lypova Dolyna 1:5
16:00 Metalurg Zaporizhya - Hirnyk-Sport 2:3
17:00 Karpaty Lviv - Volyn Lutsk 2:3 aet
17:00 FC LNZ Cherkasy - Olimpik Donetsk 2:1
17:00 FK Obolon - Polissya Zhytomyr 1:0
01/09/2021 14:30 Skoruk Tomakivka - Metalist 1925 Kharkiv 0:3
15:00 MFK Mikolaiv - FK Vovchansk 4:1
3. Round
21/09/2021 15:00 MFK Mikolaiv - Rukh Lviv 0:3 (0:2)
17:00 Metalist Kharkiv - Desna Chernigov 2:1 (0:1)
22/09/2021 11:00 Tavriya Simferopol - FK Oleksandriya 1:3 (1:2)
13:00 FC LNZ Cherkasy - Inhulets Petrove 2:1 (1:1)
15:00 Volyn Lutsk - FK Mariupol 5:6 (0:0, 0:0, 0:0) pso
15:00 FK VPK-Ahro Shevchenkivka - SK Dnipro-1 1:2 (0:1)
17:00 FK Obolon - NK Veres 0:1 (0:0)
23/09/2021 11:00 Epitsentr Dunaivtsi - Metalist 1925 Kharkiv 0:1 (0:0)
13:00 Hirnyk-Sport - FK Lviv 0:2 (0:2)
15:00 Prykarpattya Ivano-Frankivsk - Chernomorets Odessa 1:4 (0:2)
17:00 Alians Lypova Dolyna - FC Mynai 3:2 (2:2)
Round of 16
26/10/2021 17:30 Metalist 1925 Kharkiv - FK Oleksandriya 2:5 (0:2)
27/10/2021 12:00 NK Veres - Vorskla Poltava 1:3 (0:1)
15:00 FK Mariupol - Dinamo Kiev 1:2 (0:2)
17:30 Chernomorets Odessa - Shakhtar Donetsk 0:3 (0:0)
28/10/2021 12:00 Alians Lypova Dolyna - FK Lviv 2:3 (1:1, 1:1, 1:1) pso
15:00 Rukh Lviv - Zorya Lugansk 0:2 (0:0, 0:0) aet
17:30 Metalist Kharkiv - Kolos Kovalivka 1:0 (1:0)
01/12/2021 17:00 FC LNZ Cherkasy - SK Dnipro-1 0:2 (0:1)
Quarter-finals
01/03/2022 Metalist Kharkiv - Zorya Lugansk dnp
02/03/2022 FK Oleksandriya - Dinamo Kiev dnp
FK Lviv - Shakhtar Donetsk dnp
03/03/2022 SK Dnipro-1 - Vorskla Poltava dnp