 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 04/05/2022 | 15:00 | Deportivo Toluca | - | CF América | 0:1 (0:0) | |
| 05/05/2022 | 15:00 | Deportivo Guadalajara | - | Club Tijuana | 0:2 (0:1) | |
| 17:00 | Santos Laguna | - | Club León | 1:0 (0:0) | ||
| 17:00 | UANL Tigres | - | CF Pachuca | 4:2 (2:0) | ||
| 07/05/2022 | 15:30 | CF América | - | Deportivo Toluca | 4:0 (1:0) | |
| 08/05/2022 | 15:00 | Club León | - | Santos Laguna | 5:2 (2:0) | |
| 18:00 | CF Pachuca | - | UANL Tigres | 1:0 (1:0) | ||
| 09/05/2022 | 03:00 | Club Tijuana | - | Deportivo Guadalajara | 1:0 (1:0) | |
| Semi-finals | ||||||
| 12/05/2022 | 03:00 | Club Tijuana | - | CF América | 1:0 (0:0) | |
| 17:00 | UANL Tigres | - | Club León | 1:0 (1:0) | ||
| 14/05/2022 | 15:00 | CF América | - | Club Tijuana | 1:0 (0:0) | |
| 15/05/2022 | 15:00 | Club León | - | UANL Tigres | 3:3 (1:1) | |
| Final | ||||||
| 19/05/2022 | 01:00 | UANL Tigres | - | CF América | 0:2 (0:1) | |
| 21/05/2022 | 16:00 | CF América | - | UANL Tigres | 3:1 (1:0) | |
