| League One | M. | W | D | L | goals | |||
| at home | 8 | 5 | 1 | 2 | 14 | : | 7 | |
| Away | 8 | 4 | 1 | 3 | 8 | : | 6 | |
| ∑ | 16 | 9 | 2 | 5 | 22 | : | 13 | |
| League Two | M. | W | D | L | goals | |||
| at home | 1 | 1 | 0 | 0 | 2 | : | 0 | |
| Away | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| ∑ | 2 | 1 | 1 | 0 | 3 | : | 1 | |
| EFL Trophy | M. | W | D | L | goals | |||
| Away | 1 | 0 | 0 | 1 | 1 | : | 4 | |
| ∑ | 1 | 0 | 0 | 1 | 1 | : | 4 | |
| overall | M. | W | D | L | goals | |||
| at home | 9 | 6 | 1 | 2 | 16 | : | 7 | |
| Away | 10 | 4 | 2 | 4 | 10 | : | 11 | |
| Neutral Place | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 19 | 10 | 3 | 6 | 26 | : | 18 | |
| League Two | |||||
| 2006/2007 | 33. Round | Bristol Rovers | - | Milton Keynes Dons | 1:1 (0:0) |
| 2006/2007 | 4. Round | Milton Keynes Dons | - | Bristol Rovers | 2:0 (1:0) |
| EFL Trophy | |||||
| 2022/2023 | Round of 16 | Bristol Rovers | - | Milton Keynes Dons | 4:1 (1:0) |
|
For games that were decided on penalties the score after 120 minutes will be included in the ranking |
England 
![Milton Keynes Dons [Women]](https://s.hs-data.com/bilder/wappen/mini/28968.gif?fallback=png "Milton Keynes Dons [Women]"){kind=small}
![Milton Keynes Dons [U18]](https://s.hs-data.com/bilder/wappen/mini/33330.gif?fallback=png "Milton Keynes Dons [U18]"){kind=small}
![Milton Keynes Dons [Youth B Women]](https://s.hs-data.com/bilder/wappen/mini/36022.gif?fallback=png "Milton Keynes Dons [Youth B Women]"){kind=small}
