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| 1st(1st leg) | Alianza Lima | - | Grêmio Porto Alegre | -:- | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Alianza Lima | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | San Antonio Bulo Bulo | - | Once Caldas | -:- | ||
| 2nd (2nd leg) | Once Caldas | - | San Antonio Bulo Bulo | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Atlético Bucaramanga | - | Atlético Mineiro | -:- | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Atlético Bucaramanga | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Bolívar | - | Palestino | -:- | ||
| 2nd (2nd leg) | Palestino | - | Bolívar | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Bahia - BA | - | América de Cali | -:- | ||
| 2nd (2nd leg) | América de Cali | - | Bahia - BA | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Independiente del Valle | - | Vasco da Gama - RJ | -:- | ||
| 2nd (2nd leg) | Vasco da Gama - RJ | - | Independiente del Valle | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Universidad de Chile | - | Guaraní | -:- | ||
| 2nd (2nd leg) | Guaraní | - | Universidad de Chile | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
| 1st(1st leg) | Central Córdoba SdE | - | Cerro Largo | -:- | ||
| 2nd (2nd leg) | Cerro Largo | - | Central Córdoba SdE | -:- | ||
| 1st(1st leg): 15/07/2025 | 2nd (2nd leg): 22/07/2025 | |||||
