13. Round | 20/11/2021 | Sparta Rotterdam | - | FC Twente | 0:1 | ||||
14. Round | 28/11/2021 | FC Twente | - | Feyenoord | 0:0 | ||||
15. Round | 05/12/2021 | Go Ahead Eagles | - | FC Twente | 1:2 | ||||
16. Round | 12/12/2021 | FC Twente | - | RKC Waalwijk | 2:1 | ||||
17. Round | 18/12/2021 | PEC Zwolle | - | FC Twente | 1:3 | ||||
20. Round | 22/01/2022 | Willem II | - | FC Twente | 0:1 | ||||
21. Round | 05/02/2022 | FC Twente | - | Vitesse | 3:0 | ||||
22. Round | 13/02/2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
23. Round | 20/02/2022 | FC Twente | - | Go Ahead Eagles | 2:2 | ||||
24. Round | 25/02/2022 | RKC Waalwijk | - | FC Twente | 1:2 | ||||
26. Round | 13/03/2022 | AZ Alkmaar | - | FC Twente | 0:1 | ||||
27. Round | 19/03/2022 | FC Twente | - | PEC Zwolle | 1:0 | ||||
28. Round | 02/04/2022 | FC Twente | - | PSV Eindhoven | 3:3 | ||||
30. Round | 22/04/2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
31. Round | 30/04/2022 | Heracles Almelo | - | FC Twente | 1:1 | ||||
32. Round | 07/05/2022 | FC Twente | - | Fortuna Sittard | 1:2 | ||||
33. Round | 11/05/2022 | FC Twente | - | FC Groningen | 3:0 | ||||
34. Round | 15/05/2022 | Feyenoord | - | FC Twente | 1:2 |