6. Round | 26/09/2021 | Southampton FC | - | Wolverhampton Wanderers | 0:1 | ||||
17. Round | 15/12/2021 | Crystal Palace | - | Southampton FC | 2:2 | ||||
20. Round | 28/12/2021 | Southampton FC | - | Tottenham Hotspur | 1:1 | ||||
24. Round | 09/02/2022 | Tottenham Hotspur | - | Southampton FC | 2:3 | ||||
26. Round | 19/02/2022 | Southampton FC | - | Everton FC | 2:0 | ||||
27. Round | 25/02/2022 | Southampton FC | - | Norwich City | 2:0 | ||||
21. Round | 10/03/2022 | Southampton FC | - | Newcastle United | 1:2 | ||||
29. Round | 13/03/2022 | Southampton FC | - | Watford FC | 1:2 | ||||
31. Round | 02/04/2022 | Leeds United | - | Southampton FC | 1:1 | ||||
33. Round | 16/04/2022 | Southampton FC | - | Arsenal FC | 1:0 | ||||
34. Round | 24/04/2022 | Brighton & Hove Albion | - | Southampton FC | 2:2 | ||||
35. Round | 30/04/2022 | Southampton FC | - | Crystal Palace | 1:2 | ||||
38. Round | 22/05/2022 | Leicester City | - | Southampton FC | 4:1 |