| 2. Round | 21/08/2021 | Athletic Bilbao | - | FC Barcelona | 1:1 | ||||
| 5. Round | 18/09/2021 | Atlético Madrid | - | Athletic Bilbao | 0:0 | ||||
| 6. Round | 21/09/2021 | Athletic Bilbao | - | Rayo Vallecano | 1:2 | ||||
| 11. Round | 26/10/2021 | Espanyol Barcelona | - | Athletic Bilbao | 1:1 | ||||
| 13. Round | 05/11/2021 | Athletic Bilbao | - | Cádiz CF | 0:1 |  |
|||
| 16. Round | 06/12/2021 | Getafe CF | - | Athletic Bilbao | 0:0 | |
|||
| 18. Round | 19/12/2021 | Athletic Bilbao | - | Real Betis | 3:2 |
Spain