| 1. Round | 29/07/2000 | EA Guingamp | - | AS Saint-Étienne | 2:2 | ||||
| 2. Round | 04/08/2000 | AS Saint-Étienne | - | Olympique Marseille | 3:0 | ||||
| 3. Round | 12/08/2000 | Toulouse FC | - | AS Saint-Étienne | 1:1 |  |
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| 4. Round | 19/08/2000 | AS Saint-Étienne | - | Girondins Bordeaux | 1:0 | ||||
| 5. Round | 27/08/2000 | AJ Auxerre | - | AS Saint-Étienne | 4:3 | ||||
| 6. Round | 06/09/2000 | AS Saint-Étienne | - | Olympique Lyonnais | 2:2 | ||||
| 7. Round | 09/09/2000 | Paris Saint-Germain | - | AS Saint-Étienne | 5:1 | ||||
| 11. Round | 14/10/2000 | CS Sedan | - | AS Saint-Étienne | 2:1 | ||||
| 12. Round | 21/10/2000 | AS Saint-Étienne | - | FC Metz | 2:0 |  |
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| 13. Round | 29/10/2000 | SC Bastia | - | AS Saint-Étienne | 0:0 | |
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| 14. Round | 04/11/2000 | AS Saint-Étienne | - | ESTAC Troyes | 4:1 | ||||
| 15. Round | 10/11/2000 | AS Saint-Étienne | - | AS Monaco | 1:0 | ||||
| 16. Round | 18/11/2000 | RC Lens | - | AS Saint-Étienne | 0:0 | ||||
| 17. Round | 26/11/2000 | AS Saint-Étienne | - | FC Nantes | 0:2 | |
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| 18. Round | 29/11/2000 | Olympique Marseille | - | AS Saint-Étienne | 2:1 | ||||
| 19. Round | 02/12/2000 | AS Saint-Étienne | - | Toulouse FC | 1:0 | |
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| 20. Round | 10/12/2000 | Girondins Bordeaux | - | AS Saint-Étienne | 2:1 |
Cameroon