2. Round | 29/08/2021 | Sassuolo Calcio | - | Sampdoria | 0:0 | ||||
3. Round | 12/09/2021 | Sampdoria | - | Inter | 2:2 | ||||
4. Round | 19/09/2021 | Empoli FC | - | Sampdoria | 0:3 | ||||
5. Round | 23/09/2021 | Sampdoria | - | SSC Napoli | 0:4 | ||||
6. Round | 26/09/2021 | Juventus | - | Sampdoria | 3:2 | ||||
7. Round | 03/10/2021 | Sampdoria | - | Udinese Calcio | 3:3 | ||||
8. Round | 17/10/2021 | Cagliari Calcio | - | Sampdoria | 3:1 | ||||
9. Round | 22/10/2021 | Sampdoria | - | Spezia Calcio | 2:1 | ||||
10. Round | 27/10/2021 | Sampdoria | - | Atalanta | 1:3 | ||||
11. Round | 30/10/2021 | Torino FC | - | Sampdoria | 3:0 | ||||
12. Round | 07/11/2021 | Sampdoria | - | Bologna FC | 1:2 | ||||
13. Round | 21/11/2021 | US Salernitana 1919 | - | Sampdoria | 0:2 | ||||
17. Round | 10/12/2021 | Genoa CFC | - | Sampdoria | 1:3 | ||||
18. Round | 19/12/2021 | Sampdoria | - | Venezia FC | 1:1 | ||||
19. Round | 22/12/2021 | AS Roma | - | Sampdoria | 1:1 | ||||
21. Round | 09/01/2022 | SSC Napoli | - | Sampdoria | 1:0 | ||||
22. Round | 15/01/2022 | Sampdoria | - | Torino FC | 1:2 | ||||
36. Round | 07/05/2022 | Lazio Roma | - | Sampdoria | 2:0 | ||||
38. Round | 22/05/2022 | Inter | - | Sampdoria | 3:0 |