2. Round | 22/08/2021 | Bayern München | - | 1. FC Köln | 3:2 | ||||
3. Round | 28/08/2021 | 1. FC Köln | - | VfL Bochum | 2:1 | ||||
4. Round | 11/09/2021 | SC Freiburg | - | 1. FC Köln | 1:1 | ||||
5. Round | 18/09/2021 | 1. FC Köln | - | RB Leipzig | 1:1 | ||||
6. Round | 25/09/2021 | Eintracht Frankfurt | - | 1. FC Köln | 1:1 | ||||
7. Round | 01/10/2021 | 1. FC Köln | - | SpVgg Greuther Fürth | 3:1 | ||||
8. Round | 15/10/2021 | 1899 Hoffenheim | - | 1. FC Köln | 5:0 | ||||
15. Round | 10/12/2021 | 1. FC Köln | - | FC Augsburg | 0:2 |