1. Round | 15/08/2021 | FC Schalke 04 II | - | 1. FC Köln II | 1:2 | ||||
2. Round | 21/08/2021 | Alemannia Aachen | - | FC Schalke 04 II | 1:1 | ||||
3. Round | 25/08/2021 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 1:0 | ||||
5. Round | 04/09/2021 | FC Schalke 04 II | - | FC Wegberg-Beeck | 2:0 | ||||
16. Round | 13/11/2021 | FC Schalke 04 II | - | SV Lippstadt 08 | 2:1 | ||||
23. Round | 29/01/2022 | FC Schalke 04 II | - | Sportfreunde Lotte | 4:1 | ||||
24. Round | 05/02/2022 | FC Wegberg-Beeck | - | FC Schalke 04 II | 1:4 |