1. Round | 24/07/2021 | Club Necaxa | - | Santos Laguna | 0:3 | ||||
2. Round | 01/08/2021 | CF América | - | Club Necaxa | 2:1 | ||||
3. Round | 07/08/2021 | Club Necaxa | - | Cruz Azul | 1:2 | ||||
4. Round | 13/08/2021 | Atlético San Luis | - | Club Necaxa | 0:2 | ||||
5. Round | 18/08/2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
6. Round | 23/08/2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
7. Round | 28/08/2021 | Deportivo Guadalajara | - | Club Necaxa | 2:1 | ||||
9. Round | 18/09/2021 | Club Necaxa | - | Atlas Guadalajara | 0:3 | ||||
12. Round | 04/10/2021 | UANL Tigres | - | Club Necaxa | 0:0 |