1. Round | 14/08/2021 | Everton FC | - | Southampton FC | 3:1 | ||||
2. Round | 22/08/2021 | Southampton FC | - | Manchester United | 1:1 | ||||
3. Round | 28/08/2021 | Newcastle United | - | Southampton FC | 2:2 | ||||
4. Round | 11/09/2021 | Southampton FC | - | West Ham United | 0:0 | ||||
5. Round | 18/09/2021 | Manchester City | - | Southampton FC | 0:0 | ||||
6. Round | 26/09/2021 | Southampton FC | - | Wolverhampton Wanderers | 0:1 | ||||
7. Round | 02/10/2021 | Chelsea FC | - | Southampton FC | 3:1 | ||||
8. Round | 16/10/2021 | Southampton FC | - | Leeds United | 1:0 | ||||
9. Round | 23/10/2021 | Southampton FC | - | Burnley FC | 2:2 | ||||
10. Round | 30/10/2021 | Watford FC | - | Southampton FC | 0:1 | ||||
11. Round | 05/11/2021 | Southampton FC | - | Aston Villa | 1:0 | ||||
12. Round | 20/11/2021 | Norwich City | - | Southampton FC | 2:1 | ||||
13. Round | 27/11/2021 | Liverpool FC | - | Southampton FC | 4:0 | ||||
14. Round | 01/12/2021 | Southampton FC | - | Leicester City | 2:2 | ||||
15. Round | 04/12/2021 | Southampton FC | - | Brighton & Hove Albion | 1:1 | ||||
37. Round | 17/05/2022 | Southampton FC | - | Liverpool FC | 1:2 | ||||
38. Round | 22/05/2022 | Leicester City | - | Southampton FC | 4:1 |