1. Round | 26/07/2021 | Club Tijuana | - | UANL Tigres | 1:2 | ||||
2. Round | 01/08/2021 | Deportivo Toluca | - | UANL Tigres | 3:1 | ||||
7. Round | 29/08/2021 | UANL Tigres | - | Atlas Guadalajara | 1:1 | ||||
8. Round | 12/09/2021 | UANL Tigres | - | Club León | 2:2 | ||||
11. Round | 29/09/2021 | Atlético San Luis | - | UANL Tigres | 0:3 | ||||
15. Round | 24/10/2021 | CF América | - | UANL Tigres | 1:0 |