Champions League   M. W D L goals
  at home 2 1 1 0 4 : 3
  Away 2 0 1 1 5 : 7
  4 1 2 1 9 : 10
Europa League   M. W D L goals
  at home 2 1 0 1 1 : 2
  Away 2 0 2 0 2 : 2
  4 1 2 1 3 : 4
overall   M. W D L goals
  at home 4 2 1 1 5 : 5
  Away 4 0 3 1 7 : 9
  Neutral Place 0 0 0 0 0 : 0
  8 2 4 2 12 : 14
Champions League
2015/2016 Group E AS Roma - Bayer Leverkusen 3:2 (2:0)
2015/2016 Group E Bayer Leverkusen - AS Roma 4:4 (2:2)
2004/2005 Group B AS Roma - Bayer Leverkusen 1:1 (0:0)
2004/2005 Group B Bayer Leverkusen - AS Roma 3:1 (0:1)
Europa League
2023/2024 Semi-finals Bayer Leverkusen - AS Roma 2:2 (0:1)
2023/2024 Semi-finals AS Roma - Bayer Leverkusen 0:2 (0:1)
2022/2023 Semi-finals Bayer Leverkusen - AS Roma 0:0 (0:0)
2022/2023 Semi-finals AS Roma - Bayer Leverkusen 1:0 (0:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking